Hematology Midterm

Monkey Intel Logo

Micro: CV + Heme/Lymph Pathogens

For this lecture, expect stems that give you a source, a classic clue, or a target cell and ask you to identify the organism. Remember there is no normal flora in the cardiovascular or lymphatic systems *wink wink*.

Bartonella henselae

What you need to know: gram-negative rod that causes cat-scratch disease. It gets into the body through a cat scratch or bite and is taken up by macrophages.

What to expect on the exam: a patient with cat exposure, fever, malaise, and regional lymphadenopathy. That is Bartonella until proven otherwise.

Sporothrix schenckii

What you need to know: a dimorphic fungus found in soil, moss, wood, and plants. It enters through a skin puncture.

What to expect on the exam: a gardener/outdoor worker with a single skin nodule that spreads into more nodules along lymphatics. The phrase they want you to think of is nodular lymphangitis.

Leishmania

What you need to know: an obligate intracellular protozoan spread by the sand fly. It lives inside macrophages.

What to expect on the exam: one of three patterns.
Cutaneous = skin ulcer.
Mucocutaneous = destructive lesions of mucosa.
Visceral = fever + splenomegaly + anemia.
If they mention sand fly + macrophages, they want Leishmania.

Parvovirus B19

What you need to know: a nonenveloped DNA virus that infects erythroid precursor cells.

What to expect on the exam: the big giveaway is slapped-cheek rash in a child. The higher-yield complication stem is aplastic crisis in someone with underlying hematologic disease, or hydrops fetalis in pregnancy.

Babesia microti

What you need to know: a protozoan parasite spread by the Ixodes tick. It infects RBCs and causes hemolysis.

What to expect on the exam: fever, fatigue, anemia, and a smear showing either ring forms or the Maltese cross. If they say Ixodes + hemolysis + Maltese cross, the answer is Babesia.

What they will probably do on the exam:
They will not ask you for every tiny detail. They will usually give one strong clue and expect you to connect it fast.
Cat + lymph node = Bartonella.

Gardener + nodules along lymphatics = Sporothrix.

Sand fly + macrophages = Leishmania.

Slapped cheek or aplastic crisis = Parvovirus B19.

Ixodes + Maltese cross = Babesia.

0% Complete